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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K6
All Species:
29.7
Human Site:
S207
Identified Species:
54.44
UniProt:
P52564
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52564
NP_002749.2
334
37492
S207
I
S
G
Y
L
V
D
S
V
A
K
T
I
D
A
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
V254
W
S
M
G
L
S
P
V
E
M
A
V
G
R
Y
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851023
334
37590
S207
I
S
G
Y
L
V
D
S
V
A
K
T
I
D
A
Cat
Felis silvestris
Mouse
Mus musculus
P70236
334
37414
S207
I
S
G
Y
L
V
D
S
V
A
K
T
I
D
A
Rat
Rattus norvegicus
Q4KSH7
419
47517
K272
S
G
R
L
V
D
S
K
A
K
T
R
S
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
S223
I
S
G
Y
L
V
D
S
V
A
K
T
M
D
A
Chicken
Gallus gallus
Q90891
398
44059
I260
L
S
L
V
E
L
S
I
G
R
Y
P
I
P
P
Frog
Xenopus laevis
Q07192
446
50082
S304
I
S
G
Q
L
V
D
S
I
A
K
T
R
D
A
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
S234
I
S
G
Y
L
V
D
S
V
A
K
T
M
D
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
S200
I
S
G
Y
L
V
D
S
I
A
K
T
I
D
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
S222
I
C
G
Q
L
E
E
S
F
A
K
T
H
D
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
L223
V
M
T
N
T
A
G
L
A
N
T
F
V
G
T
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
A516
G
N
L
V
A
S
L
A
K
T
N
I
G
C
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32
N.A.
98.8
N.A.
97.9
38.6
N.A.
75.2
34.4
43.5
80.6
N.A.
58.6
N.A.
38.2
N.A.
Protein Similarity:
100
47.8
N.A.
99
N.A.
99
53.7
N.A.
85.5
51.5
56
85.8
N.A.
74.8
N.A.
56.2
N.A.
P-Site Identity:
100
13.3
N.A.
100
N.A.
100
0
N.A.
93.3
13.3
80
93.3
N.A.
93.3
N.A.
60
N.A.
P-Site Similarity:
100
13.3
N.A.
100
N.A.
100
6.6
N.A.
100
26.6
86.6
100
N.A.
100
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.1
36
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
8
16
62
8
0
0
8
62
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
0
8
54
0
0
0
0
0
0
62
0
% D
% Glu:
0
0
0
0
8
8
8
0
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
0
% F
% Gly:
8
8
62
8
0
0
8
0
8
0
0
0
16
8
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
62
0
0
0
0
0
0
8
16
0
0
8
39
0
0
% I
% Lys:
0
0
0
0
0
0
0
8
8
8
62
0
0
0
0
% K
% Leu:
8
0
16
8
70
8
8
8
0
0
0
0
0
0
0
% L
% Met:
0
8
8
0
0
0
0
0
0
8
0
0
16
0
0
% M
% Asn:
0
8
0
8
0
0
0
0
0
8
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
0
8
0
8
8
% P
% Gln:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
8
0
0
0
0
0
0
8
0
8
8
8
0
% R
% Ser:
8
70
0
0
0
16
16
62
0
0
0
0
8
0
0
% S
% Thr:
0
0
8
0
8
0
0
0
0
8
16
62
0
0
8
% T
% Val:
8
0
0
16
8
54
0
8
39
0
0
8
8
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
47
0
0
0
0
0
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _